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. 2022 Dec 16;5(4):100651. doi: 10.1016/j.jhepr.2022.100651

Fig. 1.

Fig. 1

Identification of S217879 as a novel NRF2 activator.

(A) Chemical structure of Kelch-NRF2 interaction disruptors: (1) PPI compound with in vivo target engagement established upon i.v. infusion46 (2) PPI compound with in vivo target engagement established upon oral administration51 (3) Chemical structure of novel PPI compound with good developability profile aka S217879. (B) Overlay of X-ray structures 5GNU (compound 1, grey) and compound 3 (cyan). (C) Crystal structure of the Kelch domain of KEAP1 bound to S217879 (resolution: 1.3 Angström). PPI, protein-protein interaction.