Fig. 7.

S217879-mediated NRF2 activation leads to upregulation of the antioxidant response and suppression of a wide spectrum of genes involved in disease progression.

(A) Heatmap of differentially expressed genes from S217879-treated DIO NASH mice vs. vehicle (Log₂ fold-change cut-off >1; FDR-adjusted p value cut-off: 0.05). (B) Gene set-enrichment analysis of differentially expressed genes from DIO NASH mice treated with S217879 or vehicle (HEC 1%). Enriched pathways from gene ontology analysis. (C-E) Gene sets from Hallmark and Reactome revealed upregulated and downregulated pathways (enrichment plots). (C) Reactive oxygen species, (D) inflammatory response and (E) collagen formation. NES, normalized enrichment score.