Table 2.
Summary of modelling approach in the included studies
| References | Modelling methodology (additional complexity to the simple 3 health state structure) | Number of health states and their names |
|---|---|---|
| Weeks et al. [25] | No clear description | N/A |
| Dervaux et al. [39] | Markov modelling (health states by therapy type) | 4 in 1st line: Response to 1st line, Progression after 1st line without 2nd line, Progression after 1st line with 2nd line, Death; 3 in 2nd line: Response to 2nd line, Progression after 2nd line, Death |
| Scott and Scott [23] | Decision tree | N/A |
| Main et al. [29] | Markov modelling | 3: Progression-free, Progressed, Death |
| Hornberger et al. [27] | Markov modelling | 3: Progression-free, Progressed, Death |
| Woods et al. [42] | Markov modelling (health states by therapy type and by response) | 6: Stable disease, Partial response, Complete response, Progressive disease, Best supportive care, Death |
| Adena et al. [26] | Markov modelling | 3: Progression-free, Progressed, Death |
| Kongnakorn et al. [22] | Discrete event simulation | N/A |
| Mandrik et al. [30] | Markov modelling | 3: Progression-free, Progressed, Death |
| Becker et al. [32] | Markov modelling (health state for no treatment) | 4: Progression-free with therapy, Progression-free without therapy, Progressed, Death |
| Blommestein et al. [33] | Markov modelling (health state for no treatment) | 4: Progression-free with therapy, Progression-free without therapy, Progressed, Death |
| Casado et al. [34] | Markov modelling (health state for no treatment) | 4: Progression-free with therapy, Progression-free without therapy, Progressed, Death |
| Danese et al. [24] | Epidemiological simulation model | N/A |
| Herring et al. [40] | Markov modelling (health states by therapy type and by response) | 9: Stable disease, Partial response, Complete response, Progressive multifocal leukoencephalopathy, Progression to 2nd line, Progression to 3rd line, Progression to 4th line, Best supportive care, Death |
| Müller et al. [31] | Markov modelling | 3: Progression-free, Progressed, Death |
| Soini et al. [37] | Markov modelling (health state for no treatment) | 4: Progression-free with therapy, Progression-free without therapy, Progressed, Death |
| Buchanan et al. [19] | Markov modelling (health states by therapy type) | 5: Progression-free, Progressed, Best supportive care, Bone marrow transplant, Death |
| Chen et al. [21] | Partitioned survival modelling (health state for no treatment) | 4: Progression-free with therapy (Watchful waiting), Progression-free without therapy, Progressed, Death |
| Hatswell et al. [44] | Markov modelling (health states by therapy type) | 5: Progression-free, Progressed, Best supportive care, Bone marrow transplant, Death |
| Howard et al. [28] | Partitioned survival modelling (health states for no treatment) | 4: Progression-free with therapy (Watchful waiting), Progression-free without therapy, Progresseda, Death |
| Paquete et al. [35] | Partitioned survival modelling | 3: Progression-free, Progresseda, Death |
| Williams et al. [46] | Markov modelling | 3: Progression-free, Progressed, Death |
| Barnes et al. [38] | Markov modelling (Health state for no treatment) | 4: Progression-free with therapy, Progression-free without therapy, Progressed, Death |
| Casado et al. [43] | Partitioned survival modelling | 3: Progression-free, Progresseda, Death |
| Mistry et al. [45] | Markov modelling (Health states by therapy type) | 7: Progression-free, Progression to 2nd line, Progression to 3rd line, Progression to 4th line, Progression to 5th line, Best supportive care, Death |
| Sinha and Redekop [36] | Partitioned survival modelling | 3: Pre-progression, Post-progressiona, Death |
| Vreman et al. [41] | Partitioned survival modelling | 3: Pre-progression, Post-progressiona, Death |
| Patel et al. [20] | Markov modelling (Health states by therapy type) | 6: 1st line therapy, Progression to 2nd line, Progression to 3rd line, Progression to 4th line, Best supportive care, Death |
| Lachaine et al. [9] | Markov modelling (Health state for no treatment) | 4: Progression-free with therapy (Watchful waiting), Progression-free without therapy, Progressed, Death |
aPartitioned survival modelling was used, in which progression is not modelled directly as a state, but the time in progression state is derived from the difference in the area between the overall survival and progression-free survival curves