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. 2022 Sep 6;46(1):270–284. doi: 10.1007/s10753-022-01732-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — HIF-1α promoted cellular anabolism and inhibited the catabolism of MNPCs. a–c The expression levels of Col-2, MMP-13 and ADAMTS-5 were detected using real-time PCR. d–h The protein levels of Aggrecan, Col-2, MMP-13 and ADAMTS-5 were assayed using Western blotting. i, j The expression levels of MMP-13 were detected by immunofluorescence staining. The scale bar was 50 μm. The values were the mean of at least three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001