Fig. 3.

Leptomeningeal enhancement, cortical lesions and subpial demyelination. A, B Example of 7T FLAIR MRI of the brain in a 49-years-old woman with relapsing–remitting multiple sclerosis before (A) and after (B) the administration of gadolinium-based intravenous contrast agent. A focus of post-contrast pial/subarachnoid enhancement highlighted by white arrow. Examples of focal (C) or more extensive (D, E) subpial multiple sclerosis lesions (black arrows) with expansion within white matter/confluence with a juxtacortical lesion (E) in patients with multiple sclerosis as seen on ultrahigh resolution T2* gradient echo images at 7 Tesla. A white matter lesion is also visible in (E) (white arrow). Abbreviations: FLAIR fluid-attenuated inversion recovery, MRI magnetic resonance imaging