Fig. 1.

Mean absolute change from baseline in steatosis, tissue injury, and fibrosis biomarkers.

Mean changes from baseline ± 95% CI are shown. P values were corrected for multiple testing across all tests and biomarkers using the Benjamini-Hochberg procedure. ∗p ≤0.05; ∗∗p ≤0.01; ∗∗∗p ≤0.001; ∗∗∗∗p ≤0.0001. ADAMTS-2, a disintegrin and metalloproteinase with thrombospondin motifs 2; APRI, aspartate aminotransferase-to-platelet ratio index; CK-18 M30, caspase-cleaved cytokeratin 18; ELF, enhanced liver fibrosis; FIB-4, fibrosis-4; MRE, magnetic resonance elastography; MRI-PDFF, MRI-proton density fat fraction; PC3X, crosslinked ADAMTS-2-released N-terminal type III collagen propeptide; PGBF, pegbelfermin; PRO-C3, monomeric ADAMTS-2-released N-terminal type III collagen propeptide.