Fig. 4.

Clustering of correlation coefficients for week 24 biomarkers and histological assessments.

Canonical correlation across all non-invasive and histological metrics for 179 patients were plotted by heatmap color. Correlations with adjusted p values ≤0.1 after Benjamini-Hochberg correction were printed; clustering by Euclidean distance was performed on correlation coefficients. ALT, alanine aminotransferase; AST, aspartate aminotransferase; CK-18 M30, caspase-cleaved cytokeratin 18; ELF, enhanced liver fibrosis; FIB-4, fibrosis-4; MRI-PDFF, MRI-proton density fat fraction; NAS, non-alcoholic fatty liver disease activity score; NASH, non-alcoholic steatohepatitis; PC3X, crosslinked ADAMTS-2-released N-terminal type III collagen propeptide; PRO-C3, monomeric ADAMTS-2-released N-terminal type III collagen propeptide; TG, triglycerides.