Table 1.

Intra-observer, inter-observer repeatability and scan-rescan reproducibility for healthy.

Intra-observer (n = 20)	First measurement	Second measurement	Mean difference	P value	LCC (95% CI)	Bland–Altman 95% LoA (95% CI)	CoV (%)
Native T1 (ms)	1218 ± 24 [1189–1270]	1220 ± 22 [1187–1273]	+ 2.2	0.75	0.97 (0.92–0.99)	−12.5 (16.8, −8.2) to 8.0 (3.7, 12.3)	1.3
30-min post manganese T1 (ms)	880 ± 24 [823–922]	883 ± 17 [851–918]	+ 3.0	0.63	0.95 (0.78–0.97)	−9.1 (9–14, −3.9) to 14.8 (9.6, 19.9)	3.3
Manganese uptake (Ki, mL/100 g of tissue/min)	8.4 ± 0.7 [7.2–10.2]	8.3 ± 0.7 [8.0–8.7]	−0.01	0.91	0.99 (0.95–0.99)	− 0.6 (−0.8, −0.3) to 0.5 (0.31, 0.79)	7.1

Inter-observer (n = 20)	First observer	Second observer
Native T1 (ms)	1218 ± 24 [1189–1270]	1221 ± 27 [1183–1279]	+ 2.9	0.96	0.98 (0.91–0.99)	− 9.1 (−14, −3.9) to 14.8 (9.6, 19.9)	1.8
30-min post manganese T1 (ms)	880 ± 24 [838–930]	885 ± 28 [809–933]	+ 4.9	0.80	0.91 (078–0.96)	− 19.7 (−23.4, −9.4) to 29.3 (34.5, 15.3)	3.9
Manganese uptake (Ki, mL/100 g of tissue/min)	8.4 ± 0.7 [7.2–10.2]	8.2 ± 0.7 [7.1–10.0]	−0.04	0.96	0.96 (0.91–0.99)	− 0.7 (−0.9, −0.3) to 0.6 (0.4, 0.90)	8.9

Scan–rescan (n = 10)	Baseline scan	Repeat scan
Native T1 (ms)	1230 ± 23 [1213–1247]	1226 ± 15 [1213–1239]	−4.0	0.60	0.94 (0.76–0.98)	−12.6 (−25.1, −0.07) to 22.6 (10.1, 35.3)	1.4
30-min post manganese T1 (ms)	899 ± 28 [871–927]	894 ± 27 [867–921]	−4.5	0.71	0.92 (0.64–0.95)	−26.8 (−43.2, −12.6) to 15.7 (0.15, 31.3)	2.6
Manganese uptake (Ki, mL/100 g of tissue/min)	8.4 ± 0.7 [8.0–8.6]	8.5 ± 0.7 [7.9–9.1]	+ 0.04	0.89	0.97 (0.91–0.99)	− 0.3 (−0.6, −0.1) to 0.3 (−1.7, 1.5)	8.6

Mean ± standard deviation [95% confidence interval].

LCC Lin’s concordance correlation, LoA limits of agreement, CoV coefficient of variation.