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. 2023 Feb 27;14:1109. doi: 10.1038/s41467-023-36757-w

Fig. 2. Formation of vicinal 1-ester-2-diazo-3-keto-4-oximes from β-siloxy-α-diazovinylacetates with tert-butyl nitrite.

Fig. 2

a. Investigations on the applicability and structural confirmation, desilylation with TBAF and x-ray diffraction. Reaction conditions: tBuONO (3.5 equiv.) was added to a solution containing 6 (0.4 mmol) dropwise at 0 °C. The reaction was continued for the indicated time at room temperature. Another 1.0 equiv. of TBN was added after 24 h. bYield from reaction performed on a 1.00-g scale in parenthesis. c82% of desilylated benzyl-2-diazo-3-oxobutanoate was isolated.