Table 2.
Clinical presentation of TMA.
| Patient | Hgb (g/dL) | Platelet count (×109/L) | Cr (mg/dL) | Baseline Cr (mg/dL) | LDH (U/L) | Anuria/Oliguria | GI sx | New HTN at time of TMA diagnosis | TMA confirmed by renal biopsy |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 7.7 | 30 | 2.0 | 0.65 | 619 | Y | N | Y | N |
| 2 | 7.7 | 20 | 3.08 | 1.19 | 371 | Y | N | Y | N |
| 3 | 13 | 31 | 1.04 | 0.86 | 240 | N | N | N | Y |
| 4 | 7.9 | 10 | 11.66 | 0.8 | 2150 | N | Y | N | N |
| 5 | 12.3 | 190 | 2.40 | 0.74 | 451 | Y | N | N | N |
| 6 | 9.7 | 139 | 1.42 | 0.82 | 262 | Y | N | Y | Y |
| 7 | 9.0 | 10 | 0.92 | 0.81 | 635 | Y | N | N | N |
| 8 | 9.9 | 223 | 2.05 | 1.38 | 141 | Y | N | Y | N |
| 9 | 6.9 | 16 | 6.54 | 2.4 | 401 | N | Y | N | N |
| 10 | 10.5 | 23 | 4.63 | 1.3 | 2150 | Y | N | N | Y |
The table shows pertinent laboratory values, signs and symptoms occurring at the time of TMA diagnosis. For specific patients, definitive histo-pathologic diagnosis of TMA was obtained through renal biopsy.
Hgb hemoglobin, Cr creatinine, GI sx gastrointestinal symptoms, HTN hypertension, Y yes, N no.
Normal range values: Hgb 14–17.5 g/dl (male) and 12–15.5 (female); Plt 140–400 × 109/L, LDH normal range: 135–225 U/L.