TABLE 1.
Effects of various compounds on aflatoxin production
| Expt | Compound | Concn | Production of:
|
|
|---|---|---|---|---|
| AFG1 (pmol/mg/min) | AFB1 (pmol/mg/min) | |||
| 1a | None | 0.15 ± 0.013b (100)c | 21 ± 2.0 (100) | |
| Methyrapone | 3 mM | 0.027 ± 0.001 (18) | 7.5 ± 0.1 (35) | |
| SKF-525A | 3 mM | 0.018 ± 0.0004 (12) | 5.5 ± 0.3 (26) | |
| Imidazole | 3 mM | 0.062 ± 0.005 (42) | 9.8 ± 0.6 (46) | |
| 2d | None | 0.15 ± 0.008 (100) | 19 ± 0.03 (100) | |
| Ethoxyquin | 2 μg/ml | 0.09 (61) | 18 (95) | |
| Ethoxyquin | 5 μg/ml | 0.075 (52) | 16 (86) | |
| Ethoxyquin | 40 μg/ml | 0.027 ± 0.01 (18) | 10 ± 0.5 (55) | |
a
Dimethylformamide (final concentration, 2%) was included in the reaction mixtures as the solvent.
b
The values represent the means and differences of duplicate experiments.
c
The values in parentheses are percentages.
d
Water was included in the reaction mixtures as the solvent.