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. 2023 Feb 27;13:3328. doi: 10.1038/s41598-023-29924-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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p.(N258K) and p.(G279D) Kv 7.2 diminishes Kv 7.2 surface membrane expression. (a) Western blots analysis of Kv 7.2 protein expressions in membrane, cytoplasmic and total cell lysate of cells expressing Kv7.2WT, p.(N258K) and p.(G279D), WT Kv7.2/Kv7.3, or p.(N258K) or p.(G279D) co-expressed with Kv7.3. Non- transfected HEK293 cells was used as a negative control and GAPDH as a loading control. (b) Representative confocal microscopy images of HEK 293 cells expressing either Kv7.2WT, p.(N258K) or p.G27D. Kv7.2WT (left panel), p.(N258K) (middle panel) and G279D (right panel). Scale bar: 5 µm. (c) Representative confocal microscopy images of cells expressing Kv7.2WT, p.(N258K) and p.(G279D), WT Kv7.2/Kv7.3, or p.(N258K) or p.(G279D) co-expressed with Kv7.3. Scale bar: 5 µm.