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. 2023 Feb 27;13:3328. doi: 10.1038/s41598-023-29924-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Whole cell patch clamp recordings of K + currents in of heterotetrameric Kv7.2/Kv7.3 channels. K + currents recorded in non-transfected cells or cells expressing Kv7.2/7.3 WT, p.(N258K) or p.(G279D) co-expressed with WT Kv 7.3 or WT Kv 7.2/7.3 (a) Voltage protocol with voltage-clamp steps as Fig. 3a. (b–g) Representative raw current traces for non-transfected cells (n = 22) (b), Kv7.2/Kv7.3WT (n = 22) (c), p.(N258K)/Kv7.3 (n = 14) (d), p.(G279D)/Kv7.3(n = 15) (e), Kv7.2/p.(N258K) /Kv7.3 (n = 13) (f), Kv7.2/G279D/Kv7.3(n = 14) (g). (h) average peak M-current densities (pA/pF) at + 50 mV. (i) Conductance–voltage (I–V) curves, significant differences from − 50 to + 50 mV. (j) membrane resistance (Rm). (k) membrane time constant (Tau). One-way ANOVA followed by Tukey post-hoc test, *p < 0.05, **p < 0.01, ***p < 0.001 based on one-way ANOVA Tukey test.