Table 3.
Vessel parameter for three branch level sub-groups
| 1 | 2 | 3 | p‡ | ||
|---|---|---|---|---|---|
| Artery | |||||
| Vessel number | Control | 93 | 204 | 87 | |
| POAG | 159 | 273 | 48 | ||
| Mean deviation-(SEM), dB | POAG | − 3.7 (0.5) | − 4.4 (0.4) | − 3.1 (0.6) | 0.117 |
| Diameter-(SEM), MU | Control | 112.6 (1.7) | 91.7 (1.0) | 83.7 (1.3) | < 0.001 |
| POAG | 99.4 (1.0) | 87.2 (0.8) | 80.1 (1.5) | < 0.001 | |
| p† | < 0.001 | < 0.001 | 0.128 | ||
| dila%-(SEM), % over baseline | Control | 3.7 (0.3) | 3.5 (0.1) | 3.6 (0.3) | 0.908 |
| POAG | 4.2 (0.2) | 4.1 (0.2) | 4.4 (0.4) | 0.31 | |
| p† | 0.236 | 0.617 | 0.060 | ||
| constr%-(SEM), % over baseline | Control | − 1.8 (0.1)23 | − 2.8 (0.1)1 | − 3.0 (0.2)1 | < 0.001 |
| POAG | − 3.2 (0.2) | − 3.6 (0.2) | − 3.9 (0.4) | 0.085 | |
| p† | < 0.001 | < 0.001 | 0.034§ | ||
| AUCd-(SEM), % * s | Control | 39.8 (3.5) | 35.1 (1.9) | 29.5 (3.0) | 0.051 |
| POAG | 39.3 (2.8) | 36.6 (2.3) | 37.7 (4.5) | 0.317 | |
| p† | 0.792 | 0.254 | 0.070 | ||
| AUC c-(SEM), % * s | Control | − 31.5 (2.9)23 | − 52.9 (4.9)1 | − 53.5 (5.9)1 | 0.004 |
| POAG | − 65.2 (6.4) | − 73.8 (4.5) | − 86.6 (14.4) | 0.260 | |
| p† | < 0.001 | 0.002 | 0.102 | ||
| tdila-(SEM), s | Control | 43.9 (0.7) | 43.1 (0.4) | 43.3 (0.6) | 0.241 |
| POAG | 43.4 (0.5) | 42.1 (0.4) | 40.5 (0.9) | 0.01§ | |
| p† | 0.407 | 0.070 | 0.009§ | ||
| tconstr-(SEM), s | Control | 85.8 (2.8) | 79.4 (1.7) | 76.4 (2.8) | 0.012§ |
| POAG | 78.4 (2.0) | 80.6 (1.6) | 80.9 (3.7) | 0.642 | |
| p† | 0.014§ | 0.650 | 0.196 | ||
| Vein | |||||
| Vessel number | Control | 118 | 184 | 71 | |
| POAG | 185 | 252 | 75 | ||
| Mean deviation-(SEM), dB | POAG | − 3.3 (0.4) | − 4.0 (0.4) | − 5.4 (0.8) | 0.122 |
| Diameter-(SEM), MU | Control | 133.3 (2.2) | 97.8 (1.6) | 88.1 (2.5) | < 0.001 |
| POAG | 124.9 (1.7) 23 | 96.8 (1.2) 13 | 82.6 (1.5) 23 | < 0.001 | |
| p† | 0.001 | 0.851 | 0.207 | ||
| dila%-(SEM), % over baseline | Control | 4.5 (0.2)3 | 4.1 (0.2) | 3.7 (0.2)1 | 0.018§ |
| POAG | 5.2 (0.2) | 5.2 (0.2) | 4.7 (0.5) | 0.126 | |
| p† | 0.073 | 0.011§ | 0.102 | ||
| constr%-(SEM), % over baseline | Control | − 1.7 (0.1) 23 | − 2.3 (0.1) 13 | − 2.4 (0.3) 12 | < 0.001 |
| POAG | − 2.1 (0.1) | − 3.0 (0.2) | − 3.1 (0.2) | < 0.001 | |
| p† | 0.003§ | 0.018§ | 0.014§ | ||
| AUCd-(SEM), % * s | Control | 48.7 (2.5) 23 | 38.5 (2.2) 1 | 30.1 (2.6) 1 | < 0.001 |
| POAG | 54.2 (2.6) | 49.4 (3.0) | 42.2 (5.4) | 0.003 | |
| p† | 0.388 | 0.055 | 0.119 | ||
| AUCc-(SEM), % * s | Control | − 24.4 (4.4) 23 | − 37.7 (4.3) 1 | − 45.2 (11.1) 1 | < 0.001 |
| POAG | − 30.8 (3.1) 23 | − 55.5 (5.0) 1 | − 61.2 (9.8) 1 | 0.002 | |
| p† | < 0.001 | < 0.002 | 0.015§ | ||
| tdila-(SEM), s | Control | 46.8 (0.4) 2 | 44.8 (0.4) 1 | 45.1 (0.6) | < 0.001 |
| POAG | 46.3 (0.3) | 44.8 (0.3) | 44.9 (0.6) | 0.02§ | |
| p† | 0.245 | 0.630 | 0.867 | ||
| tconstr-(SEM), s | Control | 83.7 (3.3) | 77.4 (2.7) | 77.1 (4.2) | 0.352 |
| POAG | 87.6 (2.6) | 88.4 (2.1) | 82.0 (3.8) | 0.34 | |
| p† | 0.388 | 0.002§ | 0.502 |
†Mann–Whitney U test. ‡Kruskal–Wallis test. dila%, maximal dilation, peak dilatation during a 20-s flickering period compared to baseline; tdila, time to maximal dilation, time to peak dilatation after flicker onset; constr%, maximal constriction, peak constriction after flicker onset compared to baseline; tconstr, time to maximal constriction, time to reach peak constriction; AUCd, area under the curve above baseline during flicker stimulation; AUCc, area under the response curve below baseline after flicker onset. §Statistical trend