Table 2.
Studies of pregnancy following UAE for fibroids (Mara et al. 2008; Daniels et al. 2021; Holub et al. 2008; Mara et al. 2012; McLucas et al. 2001; Pron et al. 2005; Kim et al. 2008; Pinto Pabón et al. 2008; McLucas 2013; Pisco et al. 2017; Torre et al. 2017; Walker and McDowell 2006; Hirst et al. 2008; Bonduki et al. 2011; Serres-Cousine et al. 2021; Ravina et al. 2000; Firouznia et al. 2009)
| Study, year | Study design | Comparison | Cohort size (n) | Number trying to conceive (n) | Follow up (months) | Mean age (y) | Total pregnancies (n) | Pregnancy rate (actual number of women who became pregnant/those trying to conceive) | Live births (rate) | Miscarriages (rate) |
|---|---|---|---|---|---|---|---|---|---|---|
| Mara et al. 2008 | RCT | Myomectomy | 58 | 26 | 24.9 | 32.2 | 17 | 13/26 (50%) | 5/17 (29.4%) | 9/17 (52.9%) |
| Daniels et al. 2021 | RCT | Myomectomy | 98 | 47 | 48 | 41 | 15 | 12/47 (25.5%) | 9/15 (60%) | 5/15 (33%) |
| Holub et al. 2008 | Non-randomised controlled trial | Laparoscopic uterine artery occlusion | 112 | 39 | NS | 32.3 | 28 | 20/39 (51.2%) | 10/28 (35.7%) | 14/25 (56%) |
| Mara et al. 2012 | Non-randomised controlled trial | Laparoscopic uterine artery occlusion | 100 | 42 | NS | 33.1 | 42 | 29/42 (69%) | 23/42 (54.7%) | 13/42 (31%) |
| McLucas et al. 2001 | Prospective cohort | N/A | 400 | 52 (< 40 years old) | 16 | N/S | 17 | 14/52 (26.9%) | 10/17 (58.8%) | 5/17 (29.4%) |
| Pron et al. 2005 | Prospective cohort | N/A | 555 | 35 | 24 | 34 | 24 | 21/34 (61.8%) | 18/24 (75%) | 4/24 (16.7%) |
| Kim et al. 2008 | Prospective cohort | N/A | 87 | 19 | 45 | 36.6 | 15 | 12/19 (63.2%) | 6/15 (40%) | 3/15 (20%) |
| Pinto Pabón et al. 2008 | Prospective cohort | N/A | 100 | 57(39 patients < 40 years old) | NS | 35 | 11 | 10/57 (17.5%) | 8/11 (72.7%) | 3/11 (27.3%) |
| McLucas 2013 | Prospective cohort | N/A | 44 | 40 (< 40 years old) | NS | 33.4 | 28 | 22/40 (55%) | 20/28 (71.4%) | 3/28 (10.7%) |
| Pisco et al. 2017 | Prospective cohort | N/A | 359 | 359 | 69 | 35.9 | 182 | 149/359 (41.5%) | 150/182 (82.4%) | 23/182 (12.6%) |
| Torre et al. 2017 | Prospective cohort | N/A | 15 | 15 | 43.1 | 34.8 | 12 | 8/15 (53.3%) | 10/12 (83.3%) | 1/12 (8.3%) |
| Walker and McDowell 2006 | Retrospective cohort | N/A | 1200 | 108 | NS | NS | 56 | 33/108 (30.5%) | 33/56 (58.9%) | 17/56 (30.4%) |
| Hirst et al. 2008 | Retrospective cohort | Hysterectomy | 649 | 187 | 55.2 | 43.8 | 37 | 27/187 (14.4%) | 19/37 (51.4%) | 15/37 (40.5%) |
| Bonduki et al. 2011 | Retrospective cohort | N/A | 187 | 75 | 42 | 34.3 | 15 | 15/75 (20%) | 14/15 (93%) | 1/15 (6.7%) |
| Serres-Cousine et al. 2021 | Retrospective cohort | N/A | 398 | 158 | NS | 43 | 148 | 102/158 (64.6%) | 109/148 (73.6%) | 26/148 (17.6%) |
| Ravina et al. 2000 | Case series | N/A | 9 | 9 | NS | 36 | 12 | 9/9 (100%) | 7/12 (58.3%) | 5/12 (41.7%) |
| Firouznia et al. 2009 | Case series | N/A | 102 | 23 | 24 | 35.7 | 15 | 14/23 (60.9%) | 13/15 (86.7%) | 2/15 (13.3%) |
| Redecha Jr et al. 2013 | Case series | N/A | 98 | 21 | 48 | 38.7 | 7 | 6/21 (28.6%) | 7/7 (100%) | 0 |
| TOTAL | 516/1311 (39.4%) | 471/681 (69.2%) | 149/678 (22%) |
N/A not applicable, NS not stated