Table 3.
Knowledge of Oncologists Toward Chemotherapy Resistance
| Items | Strongly Disagree |
Disagree | Uncertain | Agree | Strongly Agree |
|---|---|---|---|---|---|
| 1. I know what chemotherapy resistance is | 0 (0) | 1 (1.6) | 9 (14.1) | 40 (62.5) | 14 (21.8) |
| 2. I am aware that chemotherapy resistance can exist among cancer patients. | 0 (0) | 2 (3.2) | 5 (7.8) | 43 (67.2) | 14 (21.8) |
| 3. I am aware that chemotherapy resistance can happen at any stage of cancer disease | 0 (0) | 2 (3.2) | 14 (21.8) | 35 (54.7) | 13 (20.3) |
| 4. I have sufficient knowledge about how to use chemotherapy appropriately for my current practice | 0 (0) | 10 (15.7) | 14 (21.8) | 25 (39.1) | 15 (23.4) |
| 5. I am aware of the activities and lifestyle habits that should be avoided to counter chemotherapy resistance. | 2 (3.2) | 12 (18.8) | 16 (25) | 22 (34.4) | 12 (18.8) |
| 6. I have sufficient knowledge about Chemotherapy-Resistance-Test (CRT-test) |
1 (1.6) | 10 (15.6) | 25 (39.1) | 21 (32.8) | 7 (10.9) |
| 7.I used to ask for CTR-test prior to chemotherapy administration | 3 (4.8) | 20 (31.3) | 21 (32.8) | 15 (23.4) | 5 (8) |
| 8. When CTR-test result showed slight resistance (SR), this means the treatment plan most likely would not lead to an effective chemotherapy |
0 (0) | 13 (20.3) | 30 (46.9) | 18 (28.1) | 3 (4.8) |
| 9. When CTR-test result showed extreme resistance (ER), a new chemotherapy treatment should be planned |
0 (0) | 4 (6.3) | 15 (23.4) | 37 (57.8) | 8 (12.5) |
| 10. When CTR-test result showed medium resistance (MR), this means the probability of therapeutic failure is low |
0 (0) | 10 (15.6) | 36 (56.3) | 17 (26.6) | 1 (1.6) |
| 11. Chemotherapy resistance is a critical health issue worldwide | 3 (4.7) | 6 (9.4) | 16 (25) | 29 (45.3) | 10 (15.6) |
| 12. Chemotherapy resistance can be transmitted from one cancer patient to another | 20 (31.3) | 27 (42.2) | 12 (18.8) | 5 (7.8) | 0 (0) |
| 13. Every cancer patient treated with chemotherapy is at high risk of chemotherapy resistance |
3 (4.7) | 25 (39.1) | 16 (25) | 16 (25) | 4 (6.3) |
| 14. Misuse of chemotherapy can lead to chemotherapy resistance | 1 (1.6) | 14 (21.9) | 20 (31.3) | 23 (35.9) | 4 (6.3) |
| 15. Chemotherapy resistance occurs when cancer cells become resistant to chemotherapy, and they no longer work as well | 2 (3.2) | 13 (20.3) | 24 (37.5) | 24 (37.5) | 1 (1.6) |
| 16. Chemotherapy resistance occurs because of a gene-mutation happened in the cancer tissue | 2 (3.2) | 2 (3.2) | 22 (34.3) | 35 (54.7) | 3 (4.7) |
| 17. Chemotherapy resistance occurs because of cancer cells may pump the drug out of the cell as fast as it is going in using a molecule called p-glycoprotein |
0 (0) | 12 (18.8) | 37 (57.8) | 13 (20.3) | 2 (3.2) |
| 18. Chemotherapy resistance occurs because of cancer cells may stop taking in the drugs because the protein that transports the drug across the cell wall stops working |
0 (0) | 5 (7.8) | 33 (51.6) | 23 (35.9) | 3 (4.7) |
| 19. Chemotherapy resistance occurs because of the cancer cells may learn how to repair the DNA breaks caused by some anti-cancer drugs. | 0 (0) | 4 (6.3) | 35 (54.7) | 17 (26.6) | 8 (12.5) |
| 20. Chemotherapy resistance occurs because of cancer cells may develop a mechanism that inactivates the drug |
2 (3.2) | 6 (9.4) | 28 (43.8) | 24 (37.5) | 4 (6.3) |
| 21. Chemotherapy resistance occurs because of some of the cancer cells that are not killed by the chemotherapy mutate (change) and become resistant to the drug. | 0 (0) | 2 (3.2) | 17 (26.6) | 34 (53.1) | 11 (17.2) |
| 22. Delaying chemotherapy plays a major role in incidence of chemotherapy resistance. | 2 (3.2) | 15 (23.4) | 23 (35.9) | 22 (34.4) | 2 (3.2) |
| 23. Reducing chemotherapy dose plays a major role in incidence of chemotherapy resistance. |
1 (1.6) | 12 (18.8) | 25 (39.1) | 26 (40.6) | 0 (0) |
| 24. Using of mono-chemotherapy rather than combination-chemotherapy plays a major role in incidence of chemotherapy resistance | 0 (0) | 23 (35.9) | 23 (35.9) | 17 (26.6) | 1 (1.6) |
| 25. Chemotherapy resistance is associated with the use of specific types of chemotherapy | 0 (0) | 13 (20.3) | 23 (35.9) | 25 (39.1) | 3 (4.7) |
| 26. The use oradministration of multiple types of chemotherapy treatments can cause chemotherapy resistance | 1 (1.6) | 20 (39.3) | 26 (40.6) | 15 (23.4) | 2 (3.2) |
| 27. Long duration (i.e., number of cycles) of chemotherapy can cause chemotherapy resistance | 1 (1.6) | 30 (46.9) | 16 (25) | 13 (20.3) | 4 (6.3) |
| 28. High dose of chemotherapy can cause chemotherapy resistance | 2 (3.2) | 35 (54.7) | 13 (20.3) | 10 (15.6) | 4 (6.3) |
| 29. Route of chemotherapy administration can play role in incidence of chemotherapy resistance | 1 (1.6) | 29 (45.3) | 21 (32.8) | 10 (15.6) | 3 (4.7) |
| 30. Anemia plays a major role in incidence of chemotherapy resistance. | 3 (4.7) | 21 (32.8) | 24 (37.5) | 15 (23.4) | 1 (1.6) |
| 31. Hormonal factors contribute to chemotherapy resistance in breast cancer. | 0 (0) | 10 (15.6) | 21 (32.8) | 31 (48.4) | 2 (3.2) |
| 32. Age is a determinant of chemotherapy resistance. | 0 (0) | 23 (35.9) | 23 (35.9) | 17 (26.6) | 1 (1.6) |
| Knowledge level (N=64) | Low knowledge: 46 (71.9%) Moderate knowledge: 18 (28.1%) High: 0 (0%) |
||||