Table 5.
Univariable and Multivariable Analysis for OS in Patients with Multi-Line Therapy
| Factors | Univariable | Multivariable | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Age, y | 0.527 | – | |||
| ≥ 50 vs <50 | 0.836 (0.479,1.458) | – | |||
| Gender | 0.603 | – | |||
| Male vs female | 0.853 (0.470,1.551) | – | |||
| IMDC | 0.031 | 0.285 | |||
| Low | Ref. | Ref. | |||
| Favorable Intermediate | 1.084 (0533,2.204) | 0.823 | 1.240 (0.606,2.538) | 0.557 | |
| High | 2.688 (1.098,6.578) | 0.03 | 2.023 (0.815,5.021) | 0.129 | |
| Histological type | 0.457 | – | |||
| ccRCC vs non-ccRCC | 0.790 (0.424,1.471) | - | |||
| cT | 0.207 | - | |||
| 3–4 vs 1–2 | 1.444 (0.816,2.555) | - | |||
| ISUP | 0.709 | - | |||
| 3–4 vs 1–2 | 1.133 (0.587,2.187) | - | |||
| Interval from diagnosis to metastasis | 0.096 | - | |||
| Metachronous vs synchronous | 0.632 (0.367,1.086) | - | |||
| Number of metastatic organ | 0.002 | 0.007 | |||
| ≥ 2 vs 1 sites | 2.480 (1.386,4.437) | 2.276 (1.256,4.123) | |||
| Lung metastases | 0.8 | - | |||
| Yes vs no | 0.931 (0.533,1.623) | - | |||
| Nephrectomy | 0.168 | - | |||
| Yes vs no | 0.570 (0.257,1.266) | - | |||
| Metastasis resection | 0.185 | - | |||
| Yes vs no | 1.551 (0.810,2.971) | - | |||
| MDT | 0.009 | 0.024 | |||
| Yes vs no | 0.486 (0.283,0.834) | 0.529 (0.304,0.929) | |||
Abbreviations: IMDC, International Metastatic renal cell carcinoma Database Consortium; ccRCC, Clear cell renal cell carcinoma; ISUP, international society of urological pathology; MDT, Multidisciplinary team.