Table 1.

Brief description of dengue NS proteins.

Non-structural Protein	Description	References
NS1	A 46kDa glycoprotein. At the start of the infection process, interacts with NS4A and NS4B transmembrane proteins.	(De Clercq, 2009; de Sousa Wu et al., 2015; Dhar Dwivedi et al., 2020)
NS2A	A hydrophobic transmembrane protein with 22-kDa and 218 amino acids. The N-terminal contains 68 amino acids in the lumen of the ER whereas the C-terminal located at the cytoplasm contains 10 amino acids.	(Egloff Benarroch et al., 2002; Dwivedi et al., 2016; Dražić et al., 2020)
NS2B	A co-factor to NS3 protease. A hydrophobic protein with 15-kDa (130 amino acids).
NS3	~69kDa multifunctional enzyme acts protease RNA triphosphatase and helicase.	(Oliveira Silva et al., 2014)
NS4A	~16kDa; highly hydrophilic on the end of its C-terminus. Suitable as a signal for translocating NS4B to ER lumen.	(Idrees and Ashfaq, 2012)
NS4B	Consists of 248 amino acids. Small integral membrane protein with high hydrophobicity.	(Xie Zou et al., 2015)
NS5	104kDa, largest NS protein. Bi-functional enzyme; N-terminal is the domain of methyltransferase and C-terminal is the polymerase RNA dependent on the RNA.	(Zhao et al., 2015)