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Mean (+SE) baseline paw-lick latencies of PD 60 male and female rats (n = 7–8/sex). Rats were pre-treated with fentanyl (10 or 100 μg/kg) or saline from PD 4 to PD 9 and injected with U50,488 (0, 5.0, 10, or 20 mg/kg, sc) on PD 60. *Significantly different from 0 mg/kg morphine.
