Table 3. Future MS conventional MRI parameters for protocol A and B.
| A. PROTOCOL A | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sequence | T1-weighted | T2-weighted | 2D FLAIR | 3D FLAIR | ||||||||||||
| EDI1 | GLA | DUN | ABN | EDI1 | GLA | DUN | ABN | EDI1 | GLA | DUN | ABN | EDI1 | GLA | DUN | ABN | |
| Mode | 3D | 3D | 3D | 3D | 2D | 2D | 2D | 3D | 2D | 2D | 2D | 2D | 3D | 3D | 3D | 3D |
| FOV (mm) | 256 | 256 | 256 | 240 | 220 | 220 | 220 | 256 | 250 | 250 | 250 | 250 | 256 | 256 x 248 | 256 x 248 | 256 |
| Orientation | Sag | Sag | Sag | Sag | Ax | Ax | Ax | Sag | Ax | Ax | Ax | Ax | Sag | Sag | Sag | Sag |
| TR (ms) | 2530 | 2500 | 2500 | 3000 | 6000 | 6160 | 6160 | 2500 | 9500 | 9500 | 9500 | 11000 | 5000 | 5000 | 5000 | 8000 |
| TE (ms) | 3.37 | 2.26 | 2.26 | 3.9 | 96 | 96 | 96 | 310 | 124 | 124 | 124 | 125 | 715 | 393 | 393 | 347 |
| TI (ms) | 1100 | 1100 | 1100 | 1048 | - | - | - | - | 2400 | 2400 | 2400 | 2800 | 1800 | 1800 | 1800 | 2400 |
| Flip angle (deg) | 7 | 7 | 7 | 8 | 150 | 150 | 150 | - | 150 | 150 | 150 | 120 | - | - | - | - |
| Gap (mm) | - | - | - | - | 1.2 | 1.2 | 1.2 | - | 0 | 0 | 0 | 1 | - | - | - | - |
| Matrix (mm) | 256 × 256 | 256 × 256 | 256 × 256 | 240 × 240 | 320 × 320 | 320 × 314 | 314 × 314 | 256 × 256 | 256 × 256 | 256 × 256 | 256 × 256 | 252 × 226 | 256 × 256 | 256 × 248 | 256 × 248 | 256 × 256 |
|
Voxel size
(mm) |
1 × 1
× 1 |
1 × 1
× 1 |
1 × 1
× 1 |
1 × 1
× 1 |
0.7 ×
0.7 × 4 |
0.7 ×
0.7 × 4 |
0.7 ×
0.7 × 4 |
1 × 1
× 1 |
1 × 1
× 3 |
1 × 1
× 3 |
1 × 1
× 3 |
1 × 1.1
× 3 |
1 × 1
× 1 |
1 × 1
× 1.3 |
1 × 1
× 1.3 |
1 × 1
× 2 |
|
Slices
reconstructed |
176 | 176 | 176 | 160 | 33 | 33 | 33 | 176 | 60 | 60 | 60 | 29 | 176 | 176 | 176 | 176 |
|
Acq. Time (m:
ss) |
6:03 | 5:59 | 5:59 | 5:38 | 1:26 | 1:03 | 1:03 | 3:42 | 7:38 | 7:38 | 7:38 | 5:08 | 7:22 | 5:32 | 5:32 | 8:32 |
| B. PROTOCOL B | ||||||||||||||||
| Sequence | T1-weighted (MPRAGE) |
T2-weighted dual echo
(FSE) |
2D FLAIR (PROPELLER) | 3D FLAIR (SPACE) | ||||||||||||
| Mode | 3D | 2D | 2D | 3D | ||||||||||||
| FOV (mm) | 256 | 250 | 250 | 256 | ||||||||||||
| Orientation | Sagittal | Axial | Axial | Sagittal | ||||||||||||
| TR (ms) | 2500 | 3630 | 9500 | 5000 | ||||||||||||
| TE (ms) | 2.26 | 9.6, 96 | 120 | 393 | ||||||||||||
| TI (ms) | 1100 | - | 2400 | 1800 | ||||||||||||
| Flip angle (deg) | 7 | 150 | 150 | - | ||||||||||||
| Gap (mm) | - | 0 | 0 | - | ||||||||||||
| Matrix (mm) | 256 x 256 | 384 x 384 | 256 x 256 | 256 x 256 | ||||||||||||
| Voxel size (mm) | 1 x 1 x1 | 0.7 x 0.7 x 3 | 1 x 1 x 3 | 1 x 1 x 1 | ||||||||||||
| Slices | 176 | 60 | 60 | 176 | ||||||||||||
| Acceleration factor (in-plane × slice) | 2 × 1 | 3 × 1 | 2 × 1 | 2 × 1 | ||||||||||||
| Acq. Time (m:ss) | 5:59 | 4:01 | 4:47 | 6:52 | ||||||||||||
MRI=magnetic resonance imaging, FLAIR = fluid attenuated inversion recovery; EDI1 = Edinburgh site 1; GLA = Glasgow; DUN = Dundee; ABN = Aberdeen; FOV = field of view; TR = repetition time; TE = echo time; TI = inversion time; deg = degree; acq. = acquisition; Sag = sagittal; Ax = axial