Table 4. FutureMS MRI sub-study parameters.
| Sequence |
MT on/MT off/T1W
Multi-echo spoiled gradient echo |
dMRI | SWI |
|---|---|---|---|
| Mode | 3D | 2D | 3D |
| FOV (mm) | 224 (SI) x 241 (AP) | 256 | 250 x 218.75 |
| Directions | - | 151 | - |
|
b-value (no. of directions)
(s/mm 2) |
- | 0
rev (3), 0 (14), 200 (3), 500 (6), 1000
(64), 2000 (64) |
- |
| Orientation | Sagittal | Axial | Sagittal |
| TR (ms) | 30/30/15 | 4300 | 64 |
| TE (ms) | 1.54, 4.55, 8.49 | 74 | 35 |
| Flip angle (deg) | 5/5/18 | - | 10 |
| Gap (mm) | 0 | 0 | 0 |
| Matrix (mm) | 160 x 172 | 128 x 128 | 384 x 336 |
| Voxel size (mm) | 1.4 × 1.4 × 1.4 | 2 × 2 × 2 | 0.65 × 0.65 ×
0.65 |
| Slices | 128 | 74 | 288 |
|
Acceleration factor (in-plane
× slice) |
2 × 1 | 2 × 2 | - |
| Acq. Time (m:ss) | 6:14/6:14/3:08 | 11:12 | 7:08 |
MRI = magnetic resonance imaging; FOV = field of view; TR = repetition time; TE = echo time; deg = degree; acq. = acquisition; rev = reverse phase-encode direction; MT = magnetization transfer; T1W = T1-weighted; dMRI = diffusion MRI; SWI = susceptibility weighted imaging