Table 2.
Twenty key target genes of Resinacein S related to NAFLD.
| Genes | Protein names | UniProt ID |
|---|---|---|
| NR1H4 | Bile acid receptor | Q96RI1 |
| CYP17A1 | Cytochrome P450 17A1 | P05093 |
| MMP1 | Matrix metalloproteinase 1 | P03956 |
| FDFT1 | Squalene synthetase | P37268 |
| TNF | TNF-alpha | P01375 |
| AGTR1 | Type-1 angiotensin II receptor (by homology) | P30556 |
| AKT1 | Serine/threonine-protein kinase AKT | P31749 |
| AKT2 | Serine/threonine-protein kinase AKT2 | P31751 |
| CYP3A4 | Cytochrome P450 3A4 | P08684 |
| DNMT1 | DNA (cytosine-5)-methyltransferase 1 | P26358 |
| ESR1 | Estrogen receptor alpha | P03372 |
| HMGCR | HMG-CoA reductase | P04035 |
| MMP2 | Matrix metalloproteinase 2 | P08253 |
| MMP9 | Matrix metalloproteinase 9 | P14780 |
| MTOR | Serine/threonine-protein kinase mTOR | P42345 |
| NOS2 | Nitric oxide synthase, inducible (by homology) | P35228 |
| PIK3CA | PI3-kinase p110-alpha subunit | P42336 |
| PTPN11 | Protein-tyrosine phosphatase 2C | Q06124 |
| SERPINA6 | Corticosteroid binding globulin | P08185 |
| SHBG | Testis-specific androgen-binding protein | P04278 |