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. 2023 Feb 2;14:1111433. doi: 10.3389/fphar.2023.1111433

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Copyright © 2023 McNally and Loizou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparisons of PBPK model predictions corresponding to the Latin Hypercube sample of 500 model runs. Panel (A) shows the concentration time profiles for MPHP in venous blood (mg/L) for the 500 samples; panel (B) shows the retained sample of 248 profiles for MPHP in venous blood (mg/L) following the rejection step; panel (C) shows rate of deposition of MPHP into the urine (bladder) (mg/h) for the retained sample; panel (D) shows rate of deposition of OH-MPHP into the urine (bladder) (mg/h) for the retained sample.