TABLE 1.
Tissue:blood partition coefficients and plasma fraction unbound predicted using Log Pow.
| DPHP | MPHP | |
|---|---|---|
| Log Po:w | 10.83 | 5.3 |
| Tissue:blood partition coefficient | ||
| Plasma | 15.5 | 25.23 |
| Adipose | 63.4 | 29.10 |
| Liver | 5.89 | 54.8 |
| Kidney | 5.89 | 15.5 |
| Muscle | 3.29 | 7.51 |
| Red blood cells | 3.01 | 6.67 |
| Gut | 7.4 | 25.2 |
| Spleen | 3.7 | 12.20 |
| Stomach a (gut) | 7.4 | 25.2 |
| Rapidly Perfused (spleen) | 3.7 | 12.20 |
| Slowly Perfused (muscle) | 3.29 | 7.51 |
| Plasma Fraction Unbound | 0.0025 | 0.0146 |
a
Compartments in italics have surrogate values from another organ compartment. The corresponding surrogate organ compartment is in parentheses.