TABLE 4.

Global prior and posterior pdarameter distributions.

Parameter	Median (95% interval)
	Prior	Posterior
FB_DPHP	0.975 (0.951, 0.999)	0.987 (0.986, 0.989)
FB_MPHP	0.950 (0.902, 0.998)	0.945 (0.922, 0.959)
DPHP_GUT_half_life	30.13 (10.67, 49.37)	42.72 (29.27, 58.21)
DPHP_half_life	6.62 (0.322, 22.34)	7.73 (5.65, 15.11)
Pbab	15.5 (1.785, 29.27)	18.17 (7.33, 29.56)
Pgub	25.23 (2.12, 48.70)	31.99 (24.11, 39.94)
Plib	25.23 (2.12, 48.70)	2.03 (1.04, 11.86)
PbaM	25.23 (2.12, 48.70)	36.86 (14.64, 49.48)
PliM	15.5 (1.785, 29.27)	6.28 (1.21, 27.55)
PguM	15.5 (1.785, 29.27)	16.89 (3.53, 28.84)
PkiM	15.5 (1.785, 29.27)	4.08 (2.18, 7.93)
K1_MPHP	2.52 (0.15, 4.87)	0.72 (0.35, 1.21)
K1_MOH	2.52 (0.15, 4.87)	2.69 (1.75, 4.59)
K1_cx	2.52 (0.15, 4.87)	1.64 (1.18, 2.42)
FracMetab_MOH	0.35 (0.21, 0.49)	0.221 (0.211, 0.242)
FracMetab_cx	0.03 (0.011, 0.049)	0.010 (0.010, 0.011)
Escape_gu	0.50 (0.028, 0.977)	0.59 (0.31, 0.83)
Escape_Li	0.50 (0.028, 0.977)	0.59 (0.45, 0.75)
${\mathit{\sigma }}_{\mathit{D}\mathit{P}\mathit{H}\mathit{P}\_\mathit{B}}$	0.67 (0.032, 2.20)	0.0048 (0.0039, 0.0065)
${\mathit{\sigma }}_{\mathit{M}\mathit{P}\mathit{H}\mathit{P}\_\mathit{B}}$	0.67 (0.032, 2.20)	0.017 (0.013, 0.022)
${\mathit{\sigma }}_{\mathit{M}\mathit{P}\mathit{H}\mathit{P}\_\mathit{U}}$	0.67 (0.032, 2.20)	0.0017 (0.0014, 0.0021)
${\mathit{\sigma }}_{\mathit{O}\mathit{H}\_\mathit{U}}$	0.67 (0.032, 2.20)	0.0085 (0.0069, 0.011)
${\mathit{\sigma }}_{\mathit{c}\mathit{x}\_\mathit{U}}$	0.67 (0.032, 2.20)	0.00042 (0.00034, 0.00052)