Table 4.
Association of genetic risk scores with diabetic nephropathy in patients with type 2 diabetes
| Variables |
n |
Diabetic nephropathy | ||
| Yes, n (%) | Crude OR (95% CI) | Adjusted OR (95% CI) | ||
| Unweighted genetic risk score, per 1 point | 2332 | 256 (10.98) | 1.01 (0.93 to 1.09) | 1.00 (0.92 to 1.09) |
| Tertile 1: 0~2 | 812 | 91 (11.21) | 1.00 | 1.00 |
| Tertile 2: 3~4 | 766 | 74 (9.66) | 0.85 (0.61 to 1.17) | 0.71 (0.49 to 1.02) |
| Tertile 3: >5 | 754 | 91 (12.07) | 1.09 (0.80 to 1.48) | 1.02 (0.72 to 1.43) |
| Weighted genetic risk score, per 1 point | 2332 | 256 (10.98) | 1.02 (0.76 to 1.37) | 1.00 (0.72 to 1.39) |
| Tertile 1: 0~0.56 | 812 | 91 (11.21) | 1.00 | 1.00 |
| Tertile 2: 0.57~1.03 | 759 | 74 (9.75) | 0.86 (0.62 to 1.18) | 0.72 (0.50 to 1.03) |
| Tertile 3: >1.03 | 761 | 91 (11.96) | 1.08 (0.79 to 1.47) | 1.00 (0.71 to 1.41) |
Multivariate model adjusting for covariates that satisfy the MR assumption 2.
*p<0.05