Table 5.
The ORs of diabetic nephropathy for predictive log-transformed hsCRP level derived from weighted and unweighted genetic risk score
| Variables |
n |
Diabetic nephropathy | |||
| Yes, n (%) | Crude OR (95% CI) | Adjusted OR (95% CI)* | Adjusted OR (95% CI)† | ||
| That of log-transformed hsCRP from unweighted genetic risk score | |||||
| Per 1 unit | 2332 | 256 (10.98) | 1.80 (1.52 to 2.14)*** | 1.80 (1.52 to 2.14)*** | 1.80 (1.51 to 2.14)*** |
| Tertile 1: <0.008 | 769 | 47 (6.11) | 1.00 | 1.00 | 1.00 |
| Tertile 2: 0.008~0.464 | 771 | 74 (9.60) | 1.63 (1.12 to 2.39)* | 1.63 (1.12 to 2.39)* | 1.70 (1.16 to 2.49)** |
| Tertile 3: >0.464 | 792 | 135 (17.05) | 3.16 (2.23 to 4.47)*** | 3.16 (2.23 to 4.47)*** | 3.19 (2.24 to 4.55)*** |
| That of log-transformed hsCRP from weighted genetic risk score | |||||
| Per 1 unit | 2332 | 256 (10.98) | 1.71 (1.44 to 2.02)*** | 1.71 (1.45 to 2.02)*** | 1.67 (1.40 to 1.98)*** |
| Tertile 1: <−0.012 | 770 | 51 (6.62) | 1.00 | 1.00 | 1.00 |
| Tertile 2: −0.012~0.464 | 769 | 73 (9.49) | 1.48 (1.02 to 2.15)* | 1.48 (1.02 to 2.15)* | 1.45 (1.00 to 2.11) |
| Tertile 3: >0.464 | 793 | 132 (16.65) | 2.82 (2.00 to 3.96)*** | 2.82 (2.01 to 3.97)*** | 2.69 (1.89 to 3.82)*** |
*p<0.05; **p<0.01; ***p<0.001.
*Adjusted OR: adjusting for residual and PCA.
†Adjusted OR: adjusting for residual, PCA and covariates that did not satisfy the MR assumption 2, respectively.
hsCRP, high-sensitivity C-reactive protein level.