FIGURE 4.

Activated pathways and mutation profiles in STING subtypes. (A) Heatmaps of GSEA normalized enrichment score (NES) for hallmark gene sets among three SCLC subtypes. (B) Heatmaps of pathways involved in DNA damage response and cell cycle regulation. (C) Mutation profiles in SCLC‐specific genes and in DNA damage response‐associated genes in each STING‐related SCLC subtype. BER, base excision repair; CPF, checkpoint factor; FA, Fanconi anemia; HRR, homologous recombination repair; MMR, mismatch repair; NER, nucleotide excision repair; NHEJ, non‐homologous end joining; TLS, DNA translesion synthesis.