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. 2022 Aug 10;12(4):4472–4485. doi: 10.1002/cam4.5129

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© 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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High BMAL1 expression was significantly associated with poor prognosis in CRC. (A) Patients in The Cancer Genome Atlas (TCGA) and Sir Run Run Shaw cohorts (n = 84) were stratified according to the BMAL1 gene expression signature. A total of 58.3% (49/84) CRC tissues were BMAL1 overexpression. Kaplan–Meyer overall survival curves of CRC with different BMAL1 genotypes (p < 0.05). (B) Representative photographs showing immunohistochemical expression of BMAL1 in the adjacent normal tissue (0 = negtive), colorectal cancer and the lymph node. 40× & 200× magnification; 1 = mild, 2 = moderate, 3 = strong.