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. 2022 Aug 10;12(4):4472–4485. doi: 10.1002/cam4.5129

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© 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Migration activity was regulated by BMAL1. (A, C) Wound‐healing assay showed that migration activity was enhanced by BMAL1. BMAL1 silencing suppressed the migration ability of SW480 cells. (B, D) Transwell assays showed that BMAL1 enhanced the migration and invasion potential of CRC. BMAL1 silencing decreased the migration and invasion of RKO and SW480 cells. (E, G) Western blot assay showed that BMAL1 significantly increased the expression of β‐catenin, N‐cadhrein, vimentin but inhibited E‐cadhrein expression. (F, H) Western blots were quantified by ImageJ densitometric analysis and normalized to controls. Data are expressed as mean ± SD (n = 3). *p < 0.05, **p < 0.01 and ***p < 0.001.