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. 2022 Aug 10;12(4):4472–4485. doi: 10.1002/cam4.5129

FIGURE 4.

FIGURE 4

BMAL1 regulates c‐Myc expression. (A) BMAL1 activated c‐Myc protein expression in RKO/BMAL1 and SW480/BMAL1 cells, which detected by western blot. (B) Western blots were quantified by ImageJ densitometric analysis and normalized to controls. Data are expressed as mean ± SD (n = 3). (C) Immunohistochemical detection of c‐Myc in representative tumor samples, the adjacent normal tissue and lymph node from CRC of the indicated genotypes. 40× & 200× magnification. 1 = mild, 2 = moderate, 3 = strong. *p < 0.05, **p < 0.01 and ***p < 0.001.