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MAPK‐signaling pathway is involved in BMAL1‐induced migration. (A) BMAL1 activated MAPK‐signaling pathway in RKO/BMAL1 and SW480/BMAL1 cells. The related proteins in MAPK‐signaling pathway were detected by western blot. BMAL1 actived the RAF, P‐MEK, P‐ERK, JNK expression, while the P38 was not affected. (B) Data are expressed as mean ± SD (n = 3). *p < 0.05, **p < 0.01 and ***p < 0.001.
