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. 2022 Aug 10;12(4):4472–4485. doi: 10.1002/cam4.5129

FIGURE 7.

FIGURE 7

BMAL1 promotes tumorigenesis and tumor metastasis in mice. (A) BMAL1 knockdown significantly inhibited CRC proliferation in vivo. Cancer cells were injected into the nude mice. The tumors were resected from mice after 35 days. (B) At the indicated times, subcutaneous tumor size (mm) was measured with calipers (mean ± SD, n = 4). (C) Immunohistochemistry staining of BMAL1 and E‐cadhrein in xenograft tissues. 40× & 200× magnification. 1 = mild, 2 = moderate, 3 = strong. *p < 0.05, **p < 0.01 and ***p < 0.001.