Table 2.
The cut-off values, sensitivity, specificity, and AUC of the pleural ADA distinguishing TPE, cancer ratio detecting MPE, and pleural LDH/ADA ratio differentiating PPE from TPE.
| Cohort 1 | Cohort 2 | Cohort 3 | All | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pleural ADA | Cancer ratio | Pleural LDH/ADA | Pleural ADA | Cancer ratio | Pleural LDH/ADA | Pleural ADA | Cancer ratio | Pleural LDH/ADA | Pleural ADA | Cancer ratio | Pleural LDH/ADA | |
| Cut off values | 14.50 | 12.61 | 12.68 | 18.50 | 13.56 | 14.53 | 22.50 | 10.92 | 11.34 | 16.50 | 12.50 | 14.29 |
| Sensitivity (%) (95% CI) | 77.78 (59.24–89.39) | 93.48 (82.50–97.76) | 100.00 (80.64–100.0) | 100.00 (85.13–100.00) | 95.12 (83.86– 99.13) | 79.41 (63.20–89.65) | 100 (64.57–100.0) | 97.06 (85.08–99.85) | 100 (30.06–98.72) | 87.50 (76.37–93.81) | 95.04 (89.60–97.71) | 81.13 (68.00–90.60) |
| Specificity (%) (95% CI) | 82.09 (71.25–89.45) | 60.00 (44.60– 73.65) | 62.50 (42.71–78.84) | 90.59 (82.51–95.15) | 70.27 (54.22–82.51) | 100.00 (84.54–100.00) | 100 (92.13–100.0) | 100 (67.56–100.0) | 75 (43.85–100.0) | 87.82 (82.51–91.67) | 67.06 (56.52–76.12) | 83.67 (70.30–92.70) |
| PLR (95%CI) | 4.34 (2.50–7.50) | 2.37 (1.60–3.50) | 2.67 (1.60–4.50) | 10.63 (5.50–20.50) | 3.20 (1.9–5.3) | NaN | NaN | NaN | 4.00 (0.70–21.80) | 7.18 (4.90–10.60) | 2.89 (2.10–3.90) | 4.97 (2.60–9.50) |
| NLR (95%CI) | 0.27 (0.10–0.60) | 0.11 (0.04–0.30) | NaN | NaN | 0.069 (0.02–0.3) | 0.21 (0.10–0.40) | NaN | 0.029 (0.004–0.20) | NaN | 0.14 (0.07–0.30) | 0.074 (0.03–0.20) | 0.23 (0.10–0.40) |
| AUC (95% CI) |
0.819 (0.715–0.923) | 0.821 (0.734–0.909) | 0.854 (0.741–0.968) | 0.970 (0.939–1.000) | 0.900 (0.836–0.965) | 0.947 (0.895–0.999) | 1.000 (1.000–1.000) | 0.996 (0.985–1.000) | 0.917 (0.691–1.000) | 0.909 (0.859–0.960) | 0.879 (0.833–0.925) | 0.888 (0.825–0.950) |
Statistical significance was set at P < 0.05.
ADA, adenosine deaminase; AUC, area under the curve; Cancer ratio, serum LDH / pleural ADA; CI, confidence interval; LDH, lactate dehydrogenase; MPE, malignant pleural effusion; NaN, the conclusion could not be performed because the values entered include one or more instances of zero; NLR, negative likelihood ration; PLR, positive likelihood ration; PPE, parapneumonic pleural effusion; TPE, tuberculous pleural effusion.