Figure 5.

Acanthopanacis Cortex restores the levels of neurotrophic factors and pro-inflammatory cytokines in CMS-induced depressive mice. The CMS-induced depressive mice were randomly divided into 5 groups as described above.The Imi, AC-L and AC-H three groups were given CMS procedure. After drug administration, the hippocampus was collected. The amounts of NGF (a), BDNF (b), GDNF (c), IL-1β (d), IL-6 (e), TNF-α (f), and IL-17 (g) in the extracts of hippocampus were detected using ELISA kits. Data are expressed in pg/mg, mean ± SEM, n = 7, *P < 0.05, **P < 0.01, ***P < 0.001 compared with CMS.