TABLE 2.

Overview of suggested considerations for researchers seeking to design studies investigating cancer related muscle dysfunction.

Consideration	Current limitations
Define the condition of interest	There is currently no standardized definition and/or assessment method for various muscle dysfunction conditions such as frailty, sarcopenia, and cancer cachexia
Determine the most appropriate outcome and method of assessment	Debate exists pertaining to the outcome variables of most importance. Namely, muscle mass and function appear to exhibit divergent results in response to exercise interventions. Additionally, methods of functional assessment are not widely agreed upon
Establish the best timepoint along the cancer continuum for intervention	Although exercise prehabilitation may be an effective strategy it is not always feasible. There is limited research on the effectiveness of exercise interventions in those receiving treatment who are also diagnosed with a muscle dysfunction condition/s
Create evidence-based recommendations for how exercise prescription can be configured/implemented to optimize outcomes	Understanding of how the manipulation of key exercise variables (I.e., frequency, intensity, type, and time) applies to conditions where muscle dysfunction is prominent remains limited