TABLE 3.
Univariate analysis for OS and PFS and multivariate analysis for OS
| Variables | PFS | OS | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Univariate analysis | Multivariate analysis | |||||||
| HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | |
| Sex, male | 1.057 | 0.771–1.449 | 0.731 | 1.356 | 0.930–1.975 | 0.110 | |||
| Age > 70 years | 1.181 | 0.862–1.622 | 0.869 | 1.522 | 1.041–2.226 | 0.030 | 1.936 | 1.164–3.219 | 0.011 |
| ECOG performance status ≥2 | 1.526 | 1.086–2.145 | 0.015 | 1.938 | 1.287–2.219 | 0.002 | 1.084 | 0.583–2.015 | 0.798 |
| Ann Arbor stage III/IV | 2.150 | 1.059–4.364 | 0.034 | 1.829 | 0.747–4.479 | 0.186 | |||
| B symptom present | 1.242 | 0.937–1.648 | 0.132 | 1.359 | 0.950–1.994 | 0.093 | |||
| Extranodal site >1 | 1.378 | 1.003–1.892 | 0.048 | 0.997 | 0.653–1.521 | 0.987 | |||
| Bone marrow involvement | 1.264 | 0.869–1.838 | 0.221 | 0.797 | 0.463–1.373 | 0.414 | |||
| Anemia a | 1.266 | 0.946–1.694 | 0.011 | 2.350 | 1.641–3.366 | 0.000 | 1.068 | 0.652–1.751 | 0.793 |
| Platelet count <100 × 109/L | 1.098 | 0.710–1.699 | 0.675 | 1.721 | 1.065–2.782 | 0.027 | 1.594 | 0.849–2.995 | 0.147 |
| Elevated LDH | 1.268 | 0.939–1.711 | 0.121 | 2.059 | 1.375–3.083 | 0.000 | 1.803 | 1.019–3.189 | 0.043 |
| Elevated β2‐MG | 1.666 | 1.132–2.451 | 0.010 | 2.360 | 1.361–4.092 | 0.002 | 1.231 | 0.650–2.332 | 0.524 |
| Albumin level < 35 g/L | 1.466 | 1.093–1.967 | 0.011 | 2.350 | 1.641–3.366 | 0.000 | 1.969 | 1.197–3.239 | 0.008 |
| CRP >3 mg/L | 1.576 | 0.980–2.536 | 0.061 | 1.805 | 0.974–3.343 | 0.060 | |||
| IgG level > 17 g/L | 1.053 | 0.601–1.844 | 0.857 | 1.730 | 0.863–3.468 | 0.122 | |||
| EBV‐DNA ≥500 copies/mL | 1.343 | 0.925–1.952 | 0.121 | 1.470 | 0.927–2.330 | 0.101 | |||
| PD‐1 positive | 1.026 | 0.547–1.924 | 0.119 | 0.789 | 0.463–1.345 | 0.341 | |||
| Background CD30 expression | 0.891 | 0.621–1.276 | 0.527 | 0.891 | 0.568–1.388 | 0.618 | |||
| Background CD8 expression | 0.727 | 0.448–1.085 | 0.119 | 0.789 | 0.463–1.345 | 0.341 | |||
| Background CD20 expression | 1.243 | 0.924–1.670 | 0.149 | 1.076 | 0.743–1.559 | 0.698 | |||
| EBER‐ ISH positive | 1.441 | 0.938–2.215 | 0.095 | 1.091 | 0.613–1.942 | 0.768 | |||
| Ki‐67 index >60% | 1.208 | 0.894–1.633 | 0.218 | 1.638 | 1.129–2.347 | 0.009 | 1.256 | 0.781–2.021 | 0.348 |
Factors with p < 0.05 were shown in bold value.
Abbreviations: CRP, C‐reactive protein; EBV, Epstein–Barr virus; ECOG, Eastern Cooperative Oncology Group; IgG, gamma globulin; LDH, lactate dehydrogenase; β2‐MG, β2‐microglobulin.
a
Hemoglobin <120 g/L in men and 110 g/L in women.