TABLE 2.
Hazard ratios and 95% confidence intervals (95% CI) for the association between race/ethnicity or genetic ancestry cluster and proportion and the risk of death adjusting for clinical variables and differentially expressed genes, where noted, in children with B‐ALL, NCI TARGET (2004–2010)
| HR (95% CI) a | HR (95% CI) b | HR (95% CI) c | HR (95% CI) d | |
|---|---|---|---|---|
| Reported Race/Ethnicity | ||||
| White | Referent | Referent | Referent | Referent |
| Black | 2.36 (1.20, 4.64) | 1.84 (0.89, 3.75) | 2.12 (0.95, 4.76) | 3.35 (1.31, 8.53) |
| Latinx | 1.59 (1.03, 2.46) | 1.51 (0.95, 2.39) | 1.60 (0.99, 2.57) | 1.47 (0.88, 2.45) |
| K‐Means Ancestry Clusters | |
| KEUR | Referent |
| KAFR | 1.91 (1.03, 3.53) |
| KAMR | 1.88 (1.22, 2.88) |
| Each 10% increase in Ancestry Proportion | |
| EUR | 0.91 (0.86, 0.96) |
| AFR | 1.11 (1.02, 1.19) |
| AMR | 1.10 (1.02, 1.18) |
| RRE‐Stratified each 10% increase in Ancestry Proportion | |
| White ‐ EUR | 0.96 (0.81, 1.14) |
| Black ‐ AFR | 5.07 (1.68, 15.24) |
| Latinx ‐ AMR | 1.16 (0.97, 1.36) |
Model adjusted for sex, age, WBC count, CNS involvement, and cytogenomic subtype.
Adjusted for sex, age, WBC count, CNS involvement, cytogenomic subtype and log2 expression of DE genes (NUP62, TMEM50B, ATP6AP2) significantly associated with survival after multiple testing adjustment (Benjamini‐Hochberg p < 0.05).
Adjusted for sex, age, WBC count, CNS involvement, cytogenomic subtype and log2 expression of DE genes (NUP62, TMEM50B, ATP6AP2, ZNF586, KANSL1‐AS1, C19orf12) significantly associated with survival without multiple testing adjustment (p < 0.05).
Adjusted for sex, age, WBC count, CNS involvement, molecular subtype and log2 expression of all 22 DE in Table S2.