TABLE 3.
Cardiotoxic adverse events
| Hypertension or cardiovascular disease (n = 155) | p1 value | p2 value | |||
|---|---|---|---|---|---|
| RCEOP (n = 49) | RCdOP (n = 76) | RCDOP (n = 30) | |||
| LVEF, n (%) | 0.653 | 0.583 | |||
| Grade 0 | 33 (67.3) | 56 (73.7) | 24 (80) | ||
| Grade 1 | 5 (10.2) | 7 (9.2) | 4 (13.3) | ||
| Grade 2 | 0 (0.0) | 2 (2.6) | 0 (0.0) | ||
| Grades 3 and 4 | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||
| NA | 11 (22.4) | 11 (14.5) | 2 (6.7) | ||
| Arrhythmia, n (%) | 0.389 | 0.136 | |||
| Grade 0 | 22 (44.9) | 26 (34.2) | 18 (60.0) | ||
| Grade 1 | 5 (10.2) | 16 (21.1) | 3 (10.0) | ||
| Grade 2 | 2 (4.1) | 6 (7.9) | 2 (6.7) | ||
| Grades 3 and 4 | 0 (0.0) | 3 (3.9) | 0 (0.0) | ||
| NA | 20 (40.8) | 25 (32.9) | 7 (23.3) | ||
| No hypertension or cardiovascular disease (n = 180) | p1 value | p2 value | |||
|---|---|---|---|---|---|
| RCEOP (n = 77) | RCdOP (n = 75) | RCDOP (n = 28) | |||
| LVEF, n (%) | 0.219 | 0.933 | |||
| Grade 0 | 53 (68.8) | 58 (77.3) | 23 (82.1) | ||
| Grade 1 | 9 (11.7) | 5 (6.7) | 2 (7.1) | ||
| Grade 2 | 0 (0.0) | 2 (2.7) | 1 (3.6) | ||
| Grades 3 and 4 | 0 (0.0) | 1 (1.3) | 0 (0.0) | ||
| NA | 15 (19.5) | 9 (12) | 2 (7.1) | ||
| Arrhythmia, n (%) | 0.802 | 0.272 | |||
| Grade 0 | 33 (42.9) | 38 (50.7) | 13 (46.4) | ||
| Grade 1 | 11 (14.3) | 8 (10.7) | 6 (21.4) | ||
| Grade 2 | 4 (5.2) | 1 (1.3) | 2 (7.1) | ||
| Grades 3 and 4 | 1 (1.3) | 1 (1.3) | 0 (0.0) | ||
| NA | 28 (36.4) | 27 (36.0) | 0 (0.0) | ||
Note: p1value: RCEOP versus RCD(d)OP; p2value: RCdOP versus RCDOP.
Abbreviation: LVEF, left ventricular ejection.