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. 2023 Jan 16;5(4):100672. doi: 10.1016/j.jhepr.2023.100672

Fig. 5.

Fig. 5

Highly elevated serum IL-6 levels are associated with a non-T-cell-inflamed TME in unresectable HCC. (A) Proportion of intratumoural immune cell subsets by CIBERSORT analysis according to serum IL-6 levels. (B) Comparison of CD8+ and CD4+ T cell CIBERSORT scores according to serum IL-6 levels. (C) Comparison of T-cell dysfunction and exclusion scores according to serum IL-6 levels. (D) Images and comparisons of CD8+ and CD4+ T cells in tumour tissues according to serum IL-6 levels. Values were compared using unpaired t tests. (A–C) n = 10 for each group. (D) n = 9 for IL-6-low and n = 8 for IL-6-high. HCC, hepatocellular carcinoma; TME, tumour microenvironment.