Table 2.
Change in PsA-modified vdH-S score | Guselkumab Q4W | Guselkumab Q8W | Placebo (W0–24)→guselkumab Q4W (W24–100) | |||||||||
W0–24 N=221 |
W24–52 N=221 |
W52–100 N=211 |
W0–100 N=211 |
W0–24 N=228 |
W24–52 N=228 |
W52–100 N=216 |
W0–100 N=216 |
W0–24 N=215 |
W24–52 N=213 |
W52–100 N=202 |
W0–100 N=204 |
|
Total | 0.5 (2.7) | 0.6 (2.7) | 0.8 (4.0) | 1.7 (7.0) | 0.7 (2.4) | 0.3 (1.6) | 0.5 (2.4) | 1.5 (4.4) | 1.1 (3.8) | 0.3 (2.8) | 0.1 (3.7) | 1.5 (6.9) |
Erosion | 0.3 (1.9) | 0.4 (1.8) | 0.4 (2.9) | 1.0 (4.7) | 0.5 (2.0) | 0.2 (1.2) | 0.3 (1.8) | 1.0 (3.4) | 0.7 (2.2) | 0.2 (1.8) | 0.1 (2.0) | 1.0 (4.0) |
Joint space narrowing | 0.2 (1.2) | 0.2 (1.1) | 0.3 (1.3) | 0.7 (2.7) | 0.2 (0.7) | 0.1 (0.7) | 0.2 (0.9) | 0.5 (1.4) | 0.4 (1.7) | 0.1 (1.1) | 0.04 (1.9) | 0.5 (3.0) |
Data presented as mean (SD).
*Reading session 3 included patients continuing study treatment at week 52 with images at weeks 0, 24, 52 and 100 (or at discontinuation after week 52).
PsA-modified vdH-S score, van der Heijde-Sharp score modified for psoriatic arthritis; Q4W, every 4 weeks; Q8W, every 8 weeks.