Table 1.

NaroNet performance: synthetic experiments. NaroNet’s classification accuracy (and 95% confidence interval) and interpretability calculated as the intersection of the most relevant extracted TME and the ground-truth of each synthetic experiment. Legend. PMI: phenotype marker expression; PF: phenotype frequency; CCI: cell-cell interaction, and NNI for neighborhood-neighborhood interaction. Index 1 refers to moderate presence, and index 2 to rare presence.

Metric / Disease Paradigm	PMI1	PMI2	PF1	PF2	CCI1	CCI2	NNI1
Accuracy (% ± Cl 95%)	93.618.9	99.710.3	99.710.3	78.113.9	98.911.0	47.815.1	86.712.0
Interpretability (%)	92.42	28.41	81.36	51.08	92.89	72.80	63.08
Contrast Accuracy (%)	59.1	71.0	58.7	55.2	52.8	58.2	78.6