Table 2.
N = 237 (progressive or stable disease = 124, partial or complete response = 113) | |||||||
---|---|---|---|---|---|---|---|
n | Estimate | OR | 95% CI | P | C-index [95% CI] | Accuracy | |
Intercept | −0.73 | 0.48 | 0.22–1.03 | 0.063 | 0.84 [0.78–0.89] | 77% | |
Std KELIM-PARP | 237 | 1.03 | 2.81 | 1.86–4.52 | <0.001 | ||
Homologous recombination deficiency (HRD) status | |||||||
BRCA mutation | 105 | REF | |||||
BRCA, wild type LOH-high | 64 | −0.96 | 0.38 | 0.18–0.77 | 0.007 | ||
BRCA, wild type LOH-low | 68 | −2.11 | 0.12 | 0.05–0.27 | <0.001 |
OR: odds ratio; 95% CI: 95% confidence interval; REF: reference class; Accuracy: repeated 10-fold cross-validation accuracy; LOH: loss-of-heterozygosity.