Table 1.

Predicted Expression Levels of the Enzymes and Metabolite Transporters Most Relevant to Metabolic Symbiosis

Protein	Expression in hypoxic cells	Expression in oxygenated cells
Glucose transporter 1 (Glut-1)	High	Low
Hexokinase (HK)	High	Low
Monocarboxylate transporter 1 (MCT-1)	Low	High
Monocarboxylate transporter 1 (MCT-4)	High	Low
Lactate dehydrogenase subunit M (LDH-M) (four subunits of LDH-M produce LDH-5)	High	Low
Lactate dehydrogenase subunit H (LDH-H) (four subunits of LDH-M produce LDH-1)	Low	High
Pyruvate dehydrogenase (PDH)	Low	High
Pyruvate dehydrogenase kinase (PDK)	High	Low