Fig. 3. (A) Cisplatin could activate NOX and catalyze O2 to form superoxide and H2O2; iron ions converted H2O2 to ·OH through the Fenton reaction. (B) Iron oxide nanoparticles containing cisplatin(iv) prodrug (FePt-NP2) could activate NOXs and catalyse O2 to form H2O2 by releasing cisplatin. H2O2 and iron ions generated excess ROS through the Fenton reaction, resulting from rapid lipid and protein oxidation and DNA damage, and triggering the ROS/CytC/caspase-3 pathway leading to apoptosis. Reproduced with permission.61 Copyright 2017, American Chemical Society.
