Fig. 5. (A) Schematic representation of MON-p53 anticancer therapy. (I) Endocytosis of MON-p53. (II) MON-triggered Fenton reaction. (III) Transfection and expression of the p53 protein. (IV) Inhibitory effect of the p53 protein on transmembrane protein SLC7A11. (V) The Fenton reaction led to LPO accumulation, and suppression of SLC7A11 expression resulting in GSH depletion. The p53 protein was involved in the apoptotic pathway and triggered apoptosis. (B) Viability of HT1080 cells after treatment with different preparations. (C) LPO, ROS and NADP⁺/NADPH contents of HT1080 cells treated with different formulations. (D) Survival curves of HT1080 tumour-bearing mice in different treatment groups. (E) Tumour volume curve of HT1080 tumour-bearing mice for 25 consecutive days. Reproduced with permission.⁷⁰ Copyright 2016, American Chemical Society.