Small molecule inducers of ferroptosis.

Ferroptosis inducers	Functional mechanism	Model systems
Erastin	Inhibit system Xc−	HCC,27 GC,28AML,29 Calu-1,4 and HT-1080 (ref. 10)
RSL3	Inhibit GPX4 directly	HT-1080,10 143B,4 and B16 (ref. 30)
Glutamate	Inhibit cystine uptake	HT-10804 and HT-22 (ref. 31)
Sulfasalazine	Inhibit system Xc−	HT-10804 and B16 (ref. 32)
Sorafenib	Inhibit system Xc−	HepG233 and HT-29 (ref. 34)
FINO2	Direct oxidation of labile iron and inactivation of GPX4	HT-1080 (ref. 35)
FIN56	Degrade GPX4	BC36 and HT-1080 (ref. 37)
DPI2	GSH depletion	HT-1080 and BJ cell lines19
Butylimine	GSH depletion	NA
Cisplatin	GSH depletion	A54938 and A2780 (ref. 25)
Buthionine sulfoximine	GSH depletion	A549,24 4T1,39 and HT-1080 (ref. 10)