Figure 16.

In vivo FAP inhibitor administration has no effect on fibrosis related gene expression in normal C67BL/6 and FBV mouse strains. Female C56BL/6 (10 weeks old; n = 5) or FBV (4 weeks old; n = 5) background health control mice were fed chow with or without FAP inhibitor (FAPi) (50 mg/kg/d) for 2 weeks. No difference of hepatic transcript levels of acta2, col1a1, tgfb1, and fap between FAPi-treated and FAPi-treated FVB and C57BL/6 mice. Data are presented as means ± standard error of the means (SEMs). Statistical analysis was performed using an unpaired 2-tailed Student t test (ns, not significant).