Figure 2.

FAP inhibition attenuates parenchymal liver fibrosis. (A–C), Livers of mice (n = 5–10/group) treated with FAPi during fibrosis progression or regression vs fibrotic untreated controls were analyzed by quantitative Sirius red and α-SMA immunohistochemistry, performed in 10 random high-power fields per mouse using ImageJ software. (D), Histological fibrosis score of liver sections. (E–F), Hepatic hydroxyproline concentration. (G), Hepatic transcript of fibrosis related transcripts. Data in (B–G) are means ± standard error of the means (SEMs). Statistical analysis was performed as for Figure 1.