Figure 6.

FAP inhibition attenuates hepatic fibrosis in Mdr2−/− mice. (A–E), Livers of nonfibrotic FBV control and biliary fibrotic Mdr2−/− mice (n = 5–10/group) were treated with FAPi (15 or 50 mg/kg/d) for 2 weeks and compared with respective untreated mice. Sirius red stained area and α-SMA-expressing cells in the parenchymal vs septal areas were assessed by quantitative morphometry in 10 high-power fields. (F–G), Total and relative hepatic hydroxyproline concentration. (H–O), Hepatic transcript levels of fibrosis related genes. Data in (B–O) are presented as means ± standard error of the means (SEMs). Statistical analysis was performed as detailed in Figure 1.